Steroid 17-alpha-Hydroxylase

A microsomal cytochrome P450 enzyme that catalyzes the 17-alpha-hydroxylation of progesterone or pregnenolone and subsequent cleavage of the residual two carbons at C17 in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP17 gene, generates precursors for glucocorticoid, androgen, and estrogen synthesis. Defects in CYP17 gene cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL) and abnormal sexual differentiation.

Also Known As:

17 alpha Hydroxylase; CYP17; Hydroxyprogesterone Aldolase; Steroid 17 alpha-Monooxygenase; 17 alpha-Hydroxylase Cytochrome P-450; 17 alpha-Hydroxyprogesterone Aldolase; 17,20-Desmolase; Cytochrome P-450(17-alpha); Cytochrome P450(17 alpha); Steroid 17 alpha-Hydroxylase; Steroid-17-Hydroxylase; 17 alpha Hydroxylase Cytochrome P 450; 17 alpha Hydroxyprogesterone Aldolase; 17 alpha-Hydroxylase, Steroid; 17 alpha-Monooxygenase, Steroid; 17,20 Desmolase; 17,20 Lyase; 17-Hydroxylase, Steroid; 17-Monooxygenase, Steroid; 17-alpha-Hydroxylase, Steroid; Aldolase, 17 alpha-Hydroxyprogesterone; Aldolase, Hydroxyprogesterone; Steroid 17 Hydroxylase; Steroid 17 Monooxygenase; Steroid 17 alpha Hydroxylase; Steroid 17 alpha Monooxygenase; alpha-Hydroxyprogesterone Aldolase, 17; alpha-Monooxygenase, Steroid 17; 17 alpha-Hydroxylase; 17,20-Lyase; Cytochrome P-450(17 alpha); P450(c17); Steroid 17-Hydroxylase; Steroid 17-Monooxygenase; Steroid, hydrogen-donor:oxygen oxidoreductase (17 alpha-hydroxylating)

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Oxidoreductases: 13899
    - Oxygenases: 336
      - Mixed Function Oxygenases: 2207
        Cytochrome P-450 Enzyme System: 5452
        Cytochrome P450 Family 17: 13
        Steroid 17-alpha-Hydroxylase: 751
        Steroid Hydroxylases: 11
        Steroid 17-alpha-Hydroxylase: 751
- Cytochromes: 2210
  - Cytochrome P-450 Enzyme System: 5452
    - Cytochrome P450 Family 17: 13
      - Steroid 17-alpha-Hydroxylase: 751
    - Steroid Hydroxylases: 11
      - Steroid 17-alpha-Hydroxylase: 751
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Hemeproteins: 196
    - Cytochromes: 2210
      - Cytochrome P-450 Enzyme System: 5452
        Cytochrome P450 Family 17: 13
        Steroid 17-alpha-Hydroxylase: 751
        Steroid Hydroxylases: 11
        Steroid 17-alpha-Hydroxylase: 751

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Disease

Drug/Important Bio-Agent (IBA)